Cat. No. 3997

Tazarotene C21H21NO2S [118292-40-3]

Price and Availability

For Tazarotene pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester

Biological Activity

Receptor-selective acetylenic retinoid; binds at retinoid acid receptors (RAR) -β and -γ. Topically used for the treatment of skin disorders, particularly psoriasis and acne. Implicated in the treatment of basal cell carcinomas; induces upregulation of Bax in vivo. Exhibits antiproliferative and proapoptotic activity. Upregulates TIGs (Tazarotene-induced genes), including the cell adhesion molecule TIG1 and the tumor-suppressor TIG3.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Son et al (2009) Expression and mutation analysis of TIG1 (Tazarotene-induced gene 1) in human gastric cancer. Oncol.Res. 17 571. PMID: 19806788.

Orlandi et al (2004) Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with Tazarotene. J.Invest.Dermatol. 122 1037. PMID: 15102095.

Higuchi et al (2003) Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lungcarcinoma cells and its association with suppression of the transformed phenotype. Oncogene 22 4627. PMID: 12879006.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Tazarotene from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Tazarotene, supplier, receptor-selective, retinoid, RARbeta, RARgamma, retinoic, acid, receptor, treats, skin, conditions, Tocris Bioscience, Retinoic Acid Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

RXR and RAR Review

Written by Alexander Moise

Retinoid Receptors Scientific Review

Our Retinoid Receptor review gives a summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Request copy or view PDF today.

divider line

New Products in this Area

EC 19

Synthetic retinoid; induces differentiation of stem cells

SI-2 hydrochloride

Steroid receptor coactivator 3 (SRC-3) inhibitor

SR 0987

T cell-specific RORγ (RORγt) agonist

WAY 252623

Potent LXR agonist

SR 9009

Rev-Erbα/β agonist

SR 9238

Potent and selective LXR inverse agonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2016

Pharmacology 2016

December 13 - 15, 2016

London, UK