Cat. No. 3996

Zotepine C18H18ClNOS [26615-21-4]

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Chemical Name: 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine

Biological Activity

5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo.

Technical Data

Soluble to 50 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Shobo et al (2010) Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J.Pharmacol.Exp.Ther. 333 772. PMID: 20223878.

Yamamura et al (2009) Effects of zotepine on extracellular levels of monamine, GABA and glutamate in rat prefrontal cortex. Br.J.Pharmacol. 157 656. PMID: 19371334.

Herrick-Davis et al (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 226. PMID: 10991983.

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Keywords: Zotepine, supplier, 5-HT2A, serotonergic, dopamine, dopaminergic, D2, histamine, H1, receptors, antagonists, 5-HT2A/D2, atypical, antipsychotic, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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