Cat. No. 3993
Alternative Name: Seocalcitol
Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-
Biological ActivityVitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bhatia et al (2009) EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol.Cancer Ther. 8 1787. PMID: 19584236.
Lu et al (2008) Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Mol.Cancer Ther. 7 1268. PMID: 18483314.
Ormerod et al (2008) The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp.Lung.Rs. 34 155.
Hoyer-Hansen et al (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 12 1297. PMID: 15905882.
Abdaimi et al (1999) Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer. Cancer Res, 59 3325.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for EB 1089 include:
Solomon et al (2014) VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res 12 1166. PMID: 24825850.
Do you know of a great paper that uses EB 1089 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: EB 1089, supplier, EB1089, VDR, agonist, Vitamin, D, receptors, seocalcitol, VDR-like, Tocris Bioscience, Vitamin D Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent LXR agonistSR 9009
Rev-Erbα/β agonistSR 9238
Potent and selective LXR inverse agonistIP7e
Potent Nurr1 activatorBexarotene
Potent and selective RXR agonistGSK 2033
Potent LXR antagonist27-Hydroxycholesterol
LXR agonist; also ER partial agonistDY 268
Potent FXR antagonistCytosporone B
High affinity Nur77 agonist
July 29 - 31, 2016