Cat. No. 3989
Chemical Name: N-(3-Aminopropyl)-2-[(3-methylpheny
Biological ActivityTRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Lashinger et al (2008) AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am.J.Physiol.Renal Physiol. 295 F803. PMID: 18562636.
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Citations are publications that use Tocris products. Selected citations for AMTB hydrochloride include:
Melikov et al (2015) Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium. Autophagy 471 221. PMID: 26272944.
Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35. PMID: 26330615.
Mueller-Tribbensee et al (2015) Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS One 10 e0128242. PMID: 26207981.
Sałat and Filipek (2015) Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. Biochem J 16 167. PMID: 25743118.
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Keywords: AMTB hydrochloride, supplier, TRPM8, transient, receptor, potential, channels, blockers, Tocris Bioscience, TRPM Blocker products