Nutlin-3

Cat. No. 3984

Nutlin-3 C30H30Cl2N4O4 [548472-68-0]

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Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Biological Activity

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Licensing Information

Sold under license from F. Hoffmann-La Roche Ltd.

Technical Data

M.Wt:
581.49
Formula:
C30H30Cl2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
548472-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844. PMID: 14704432.

If you know of a relevant reference for Nutlin-3 please let us know.

Citations are publications that use Tocris products. Selected citations for Nutlin-3 include:

Bussey et al (2016) Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. J Zhejiang Univ Sci B 5 1. PMID: 26754547.

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View Related Products by Product Action

Keywords: Nutlin-3, supplier, Nutlin3, p53, activator, MDM2, antagonist, antagonists, p53-MDM2, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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