Cat. No. 3984
Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-
Biological ActivityMDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
Licensing InformationSold under license from F. Hoffmann-La Roche Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844. PMID: 14704432.
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Citations are publications that use Tocris products. Selected citations for Nutlin-3 include:
Bussey et al (2016) Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. J Zhejiang Univ Sci B 5 1. PMID: 26754547.
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Keywords: Nutlin-3, supplier, Nutlin3, p53, activator, MDM2, antagonist, antagonists, p53-MDM2, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products