Cat. No. 3983
Chemical Name: 1-Amino-9,10-dihydro-9,10-dioxo-4-[
Biological ActivityHighly potent P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel (Cat. No. 2490), does not require bioactivation.
Licensing InformationSold with the permission of the University of Bonn.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Felix et al (2011) Development of a comprehensive set of P2 receptor pharmacological research compounds. Purinerg.Sig. 8 101. PMID: 22052555.
Baqi et al (2009) High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. J.Med.Chem. 52 3784. PMID: 19463000.
Hoffmann et al (2009) Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor. J.Pharmacol.Exp.Ther. 331 648. PMID: 19690189.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for PSB 0739 include:
Takayama et al (2016) Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system Scientific Reports 6 30006. PMID: 27445174.
Wang et al (2014) Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One 9 e110101. PMID: 25290311.
Do you know of a great paper that uses PSB 0739 from Tocris? If so please let us know.
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