Cat. No. 3977
Alternative Name: 3-MA
Chemical Name: 3-Methyl-3H-purin-6-amine
Biological ActivityInhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Canu et al (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J.Neurochem. 92 1228. PMID: 15715672.
Blommaart et al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240. PMID: 9030745.
Seglen and Gordon (1982) 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc.Natl.Acad.Sci. USA 79 1889.
If you know of a relevant reference for 3-Methyladenine please let us know.
Citations are publications that use Tocris products. Selected citations for 3-Methyladenine include:
Nepal et al (2015) Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis. Evid Based Complement Alternat Med 6 7166. PMID: 25704884.
Kim et al (2013) Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem 288 22693. PMID: 23754277.
Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Nat Commun 2013 857929. PMID: 23762164.
Wolf et al (2013) Miz1 is required to maintain autophagic flux. Clin Transl Med 4 2535. PMID: 24088869.
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Keywords: 3-Methyladenine, supplier, pi, 3-kinase, phosphatidylinositol, 3, kinase, inhibitors, inhibits, autophagy, 3-MA, pi3k, Tocris Bioscience, PI 3-kinase Inhibitor products
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