Deoxynivalenol

Cat. No. 3976

Deoxynivalenol C15H20O6 [51481-10-8]

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Alternative Names: DON, Vomitoxin

Chemical Name: 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one

Biological Activity

Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

Technical Data

M.Wt:
296.32
Formula:
C15H20O6
Solubility:
Soluble to 30 mM in ethanol
Storage:
Store at +4°C
CAS No:
51481-10-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Krishnaswamy et al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 49 50. PMID: 20347963.

Shi et al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247. PMID: 19336499.

Bae and Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59. PMID: 18502741.

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Keywords: Deoxynivalenol, supplier, DON, vomitoxin, cytotoxic, mycotoxin, protein, synthesis, inhibitors, inhibits, 3a,7a,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Tocris Bioscience, Miscellaneous Compound products

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