Cat. No. 3975
Chemical Name: (3S,11E)-3,4,5,6,9,10-Hexahydro-14,
Biological ActivityMycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Khosrokhavar et al (2009) Effects of zearalenone and α-Zearalenol in comparison with Raloxifene on T47D cells. Toxicol.Mech.Methods 19 246. PMID: 19730705.
Takemura et al (2007) Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J.Steroid Biochem.Molec.Biol. 103 170.
Kuiper et al (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139 4252. PMID: 9751507.
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Keywords: Zearalenone, supplier, estrogen, receptor, ER, ligands, mycotoxins, Tocris Bioscience, Estrogen and Related Receptor products