Milrinone

Cat. No. 1504

Milrinone C12H9N3O [78415-72-2]

Price and Availability

For Milrinone pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile

Biological Activity

Potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo. Also available as part of the Phosphodiesterase Inhibitor Tocriset™.

Technical Data

M.Wt:
211.22
Formula:
C12H9N3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
78415-72-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105. PMID: 7925608.

Shahid et al (1991) The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 104 471. PMID: 1665737.

Alousi et al (1983) Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 5 804. PMID: 6195468.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Milrinone include:

Ørstavik et al (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. Dent Res J (Isfahan) 10 e0115547. PMID: 25738589.

Roberts et al (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116 4297. PMID: 20664056.

Do you know of a great paper that uses Milrinone from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Milrinone, supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

New Products in this Area

PF 04449613

Potent PDE9 inhibitor; brain penetrant

Eggmanone

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.