AR-C 102222

Cat. No. 3969

AR-C 102222 C19H16F2N6O.HCl [253771-21-0]

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Chemical Name: 5-[(4'-Amino-5',8'-difluorospiro[piperidine-4,2'(1'H)-quinaxolin]-1-yl)carbonyl]-2-pyridinecarbonitrile hydrochloride

Biological Activity

Inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and >100 μM for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
418.83
Formula:
C19H16F2N6O.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
253771-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bonnefous et al (2009) Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J.Med.Chem. 52 3047. PMID: 19374401.

LaBuda et al (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain. Eur.J.Pain 10 505. PMID: 16125426.

Tinker et al (2003) 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J.Med.Chem. 46 913. PMID: 12620067.

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Keywords: AR-C 102222, supplier, AR-C102222, inhibits, inducible, nitric, oxide, synthase, iNOS, inhibitors, selective, astrazeneca, Tocris Bioscience, iNOS Inhibitor products

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