Cat. No. 3968
Chemical Name: 4-[2-Methyl-1-(1-methylethyl)-1H-im
Biological ActivityPotent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Byth et al (2009) AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol.Cancer Ther. 8 1856. PMID: 19509270.
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Citations are publications that use Tocris products. Selected citations for AZD 5438 include:
Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046. PMID: 24740004.
Natrajan et al (2012) Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res 14 R53. PMID: 22433433.
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Keywords: AZD 5438, supplier, AZD5438, Cdk, inhibitor, cyclin-dependent, kinase, inhibitors, inhibits, cdk1, cdk2, cdk9, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products
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