AR-A 014418

Cat. No. 3966

AR-A 014418 C12H12N4O4S [487021-52-3]

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Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea

Biological Activity

Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
308.31
Formula:
C12H12N4O4S
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
487021-52-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gould et al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387. PMID: 15315719.

Bhat et al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937. PMID: 12928438.

Bhat and Budd (2002) GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251. PMID: 12566926.

If you know of a relevant reference for AR-A 014418 please let us know.

Citations are publications that use Tocris products. Selected citations for AR-A 014418 include:

Cuesto et al (2015) GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons. PLoS One 10 e0118475. PMID: 25764078.

Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Tuberc Respir Dis (Seoul) 14 417. PMID: 25616418.

Do you know of a great paper that uses AR-A 014418 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: AR-A 014418, supplier, ARA014418, glycogen, synthase, kinase, 3, GSK-3, GSK3, inhibitors, inhibits, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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