Cat. No. 3966
Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-ni
Biological ActivitySelective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Gould et al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387. PMID: 15315719.
Bhat et al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937. PMID: 12928438.
Bhat and Budd (2002) GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251. PMID: 12566926.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for AR-A 014418 include:
Cuesto et al (2015) GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons. PLoS One 10 e0118475. PMID: 25764078.
Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Tuberc Respir Dis (Seoul) 14 417. PMID: 25616418.
Do you know of a great paper that uses AR-A 014418 from Tocris? If so please let us know.
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Keywords: AR-A 014418, supplier, ARA014418, glycogen, synthase, kinase, 3, GSK-3, GSK3, inhibitors, inhibits, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products
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