AZM 475271

Cat. No. 3963

AZM 475271 C23H27ClN4O3 [476159-98-5]

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Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy

Biological Activity

Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
442.94
Formula:
C23H27ClN4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
476159-98-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Summy et al (2005) AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol.Cancer Ther. 4 1900. PMID: 16373705.

Yezhelyev et al (2004) Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin.Cancer Res. 10 8028. PMID: 15585638.

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Citations are publications that use Tocris products. Selected citations for AZM 475271 include:

Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443. PMID: 23241962.

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Keywords: AZM 475271, supplier, AZM475271, inhibits, Src, family, tyrosine, kinase, inhibitors, astrazeneca, Tocris Bioscience, Src Kinase Inhibitor products

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