GSK 3787

Cat. No. 3961

GSK 3787 C15H12ClF3N2O3S [188591-46-0]

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Chemical Name: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

Biological Activity

Potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). Displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5).

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Palkar et al (2010) Cellular and pharmacological selectivity of the peroxisone proliferator-activated receptor-β/δ antagonist GSK3787. Mol.Pharmacol. 78 419. PMID: 20516370.

Shearer et al (2010) Identification and characterization of 4-chloro-N(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J.Med.Chem. 53 1857. PMID: 20128594.

If you know of a relevant reference for GSK 3787 please let us know.

Citations are publications that use Tocris products. Selected citations for GSK 3787 include:

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Cell Cycle 232 44105. PMID: 25300478.

Do you know of a great paper that uses GSK 3787 from Tocris? If so please let us know.

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Keywords: GSK 3787, supplier, GSK3787, peroxisome, proliferator-activated, receptor, PPARd, PPARdelta, PPARδ, antagonists, Tocris Bioscience, PPARδ Antagonist products

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