Cat. No. 3960
Chemical Name: N-[2-(Benzoylamino)-6-benzothiazoly
Biological ActivityPotent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Graf et al (2009) A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 384 166. PMID: 18831956.
Graf et al (2009) Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 74 925.
Niwa et al (2009) Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 77 389. PMID: 19323974.
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Keywords: NVP 231, supplier, NVP231, potent, reversible, selective, ceramide, kinase, CerK, inhibitors, inhibits, Tocris Bioscience, Other Kinase Inhibitor products
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