NVP 231

Cat. No. 3960

NVP 231 C25H25N3O2S [362003-83-6]

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Chemical Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[,7]decane-1-carboxamide

Biological Activity

Potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.

Technical Data

Soluble to 100 mM in DMSO and to 5 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Graf et al (2009) A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 384 166. PMID: 18831956.

Graf et al (2009) Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 74 925.

Niwa et al (2009) Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 77 389. PMID: 19323974.

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Keywords: NVP 231, supplier, NVP231, potent, reversible, selective, ceramide, kinase, CerK, inhibitors, inhibits, Tocris Bioscience, Other Kinase Inhibitor products

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