Cat. No. 3959
Chemical Name: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3
Biological ActivityGhrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Moran and Dailey (2009) Gut peptides: targets for antiobesity drug development? Endocrinology 150 2526. PMID: 19372201.
Esler et al (2007) Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 5175. PMID: 17656463.
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Keywords: YIL 781, supplier, YIL781, ghrelin, receptors, antagonists, GHS-R1a, GHSR, Tocris Bioscience, Ghrelin Receptor Antagonist products
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