Cat. No. 3954
Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)pi
Biological ActivityNicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220. PMID: 19234453.
Rosen et al (2009) Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. J.Biol.Chem. 284 34930. PMID: 19826006.
Thai et al (2009) NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. Am.J.Physiol.Renal Physiol. 297 F510. PMID: 19439521.
If you know of a relevant reference for trans-Ned 19 please let us know.
Citations are publications that use Tocris products. Selected citations for trans-Ned 19 include:
Favia et al (2016) NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Toxicol Lett 6 18925. PMID: 26733361.
Do you know of a great paper that uses trans-Ned 19 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: trans-Ned 19, supplier, NAAPD, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, ned19, Tocris Bioscience, Fluorescent Probe products
Find multiple products by catalog number
New Products in this Area
Photoactivatable cell permeable fluorescent dye; supplied as NHS esterPA Janelia Fluor® 549, SE
Photoactivatable cell permeable fluorescent dye; supplied as NHS esterCyanine 7, SE
Near-infrared fluorescent dye for labeling of aminesCyanine 3, SE
Orange fluorescent dye for labeling of aminesFFN 200 dihydrochloride
Selective fluorescent VMAT2 substrateJanelia Fluor® 646, SE
Cell permeable fluorescent dye; supplied as NHS esterJanelia Fluor® 549, SE
Cell permeable fluorescent dye; supplied as NHS ester
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.