Cat. No. 3953
Chemical Name: (1S,3S)-1-[3-[[4-(2-Fluorophenyl)pi
Biological ActivityIrreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19 (Cat. No. 3954). Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220. PMID: 19234453.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for cis-Ned 19 include:
Gerasimenko et al (2015) Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Sci Rep 58 237. PMID: 26100948.
Do you know of a great paper that uses cis-Ned 19 from Tocris? If so please let us know.
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Keywords: cis-Ned 19, supplier, cis-Ned19, NAADP, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, probes, ned19, Tocris Bioscience, General Calcium Signaling Agent products
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April 22 - 26, 2017
Chicago, IL, USA