Cat. No. 3951
Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedim
Biological ActivityPotent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655. PMID: 17958344.
Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34.
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Keywords: WZ 811, supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Tocris Bioscience, Chemokine CXC Receptor Antagonist products