WZ 811

Cat. No. 3951

WZ 811 C18H18N4 [55778-02-4]

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Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

Biological Activity

Potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).

Technical Data

Soluble to 25 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655. PMID: 17958344.

Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34.

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Keywords: WZ 811, supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Tocris Bioscience, Chemokine CXC Receptor Antagonist products

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