WZ 811

Cat. No. 3951

WZ 811 C18H18N4 [55778-02-4]

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Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

Biological Activity

Potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).

Technical Data

M.Wt:
290.36
Formula:
C18H18N4
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
55778-02-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655. PMID: 17958344.

Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34.

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Keywords: WZ 811, supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Tocris Bioscience, Chemokine CXC Receptor Antagonist products

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