CK 666

Cat. No. 3950

CK 666 C18H17FN2O [442633-00-3]

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Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Biological Activity

Inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).

Technical Data

M.Wt:
296.34
Formula:
C18H17FN2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
442633-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Han and Nolen (2009) X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors. 1751 ACSB 2009 Abstracts. American Society for Cel.

Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031. PMID: 19648907.

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Citations are publications that use Tocris products. Selected citations for CK 666 include:

Moreau et al (2015) Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest. Nat Commun 112 12151. PMID: 26371316.

Sorce et al (2015) Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement. Cell Calcium 6 8872. PMID: 26602832.

Tornavaca et al (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Proc Natl Acad Sci U S A 208 821. PMID: 25753039.

Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955. PMID: 23659999.

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Keywords: CK 666, supplier, CK666, arp2/3, actin, polymerization, inhibitors, inhibits, actin-related, proteins, arp2, arp3, Tocris Bioscience, Actin Inhibitor products

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