Cat. No. 3949
Chemical Name: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3
Biological ActivitySelective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Fell et al (2010) Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge. Neuropharmacology. 58 632. PMID: 19951716.
Johnson et al (2005) Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 179 271. PMID: 15717213.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:
Yin et al (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34 79. PMID: 24381270.
Do you know of a great paper that uses CBiPES hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CBiPES hydrochloride, supplier, positive, allosteric, modulators, PAMs, mGlu2, mGluR2, metabotropic, glutamate, group, II, receptors, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products
Find multiple products by catalog number
New Products in this Area
Negative allosteric modulator at mGlu7; brain penetrantVU 0409551
Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.