Cat. No. 3949
Chemical Name: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3
Biological ActivitySelective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fell et al (2010) Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge. Neuropharmacology. 58 632. PMID: 19951716.
Johnson et al (2005) Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 179 271. PMID: 15717213.
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Citations are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:
Yin et al (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34 79. PMID: 24381270.
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Keywords: CBiPES hydrochloride, supplier, positive, allosteric, modulators, PAMs, mGlu2, mGluR2, metabotropic, glutamate, group, II, receptors, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products