CBiPES hydrochloride

Cat. No. 3949

CBiPES hydrochloride C21H19N3O2S.HCl [856702-40-4]

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Chemical Name: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride

Biological Activity

Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.

Technical Data

M.Wt:
413.92
Formula:
C21H19N3O2S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
856702-40-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fell et al (2010) Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge. Neuropharmacology. 58 632. PMID: 19951716.

Johnson et al (2005) Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 179 271. PMID: 15717213.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:

Yin et al (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34 79. PMID: 24381270.

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Keywords: CBiPES hydrochloride, supplier, positive, allosteric, modulators, PAMs, mGlu2, mGluR2, metabotropic, glutamate, group, II, receptors, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products

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