exo-IWR 1

Cat. No. 3947

exo-IWR 1 C25H19N3O3 [1127442-87-8]

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Chemical Name: 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Biological Activity

Negative control for endo-IWR 1 (Cat.No. 3532). 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.

Technical Data

M.Wt:
409.44
Formula:
C25H19N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1127442-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lu et al (2009) Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 19 3825. PMID: 19410457.

Chen et al (2008) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100.

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Keywords: exo-IWR 1, supplier, endo-IWR, 1, endo-IWR1, negative, controls, Wnt, beta-catenin, b-catenin, β-catenin, Tocris Bioscience, β-catenin products

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