TNP

Cat. No. 3946

TNP C20H16F3N7O2 [519178-28-0]

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Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine

Biological Activity

Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).

Technical Data

M.Wt:
443.38
Formula:
C20H16F3N7O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
519178-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571. PMID: 19208622.

Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897. PMID: 12210991.

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Keywords: TNP, supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Tocris Bioscience, Other Kinase Inhibitor products

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