Colivelin

Cat. No. 3945

Colivelin Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro

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Biological Activity

Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

Technical Data

M.Wt:
2645.13
Formula:
C119H206N32O35
Sequence:
SALLRSIPAPAGASRLLLLTGEIDLP
Solubility:
Soluble to 1 mg/ml in 20% ethanol / water
Storage:
Store at -20°C
CAS No:
867021-83-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653. PMID: 19782727.

Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020. PMID: 17928813.

Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J.Neurosci. 25 10252. PMID: 16267233.

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Citations are publications that use Tocris products. Selected citations for Colivelin include:

Vergani et al (2013) Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. J Cell Biol 127 463. PMID: 23250993.

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Keywords: Colivelin, supplier, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, alzheimers, disease, STAT3, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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