Cat. No. 3945
Biological ActivityNeuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sari et al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653. PMID: 19782727.
Yamada et al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020. PMID: 17928813.
Chiba et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J.Neurosci. 25 10252. PMID: 16267233.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Colivelin from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Colivelin, supplier, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, alzheimers, disease, STAT3, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products
Find multiple products by catalog number
New Products in this Area
Mitochondrial protonophore uncouplerRS 1
High affinity RAD51 activator; also CRISPR enhancer6-Hydroxy-DL-DOPA
Allosteric inhibitor of RAD52; also APE1 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.