Cat. No. 3942
Chemical Name: N-[(-4-Fluorophenyl)methyl]-α-oxo-1H
Biological ActivityGABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723. PMID: 19469479.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TCS 1105 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TCS 1105, supplier, TCS1105, alpha2, agonist, alpha1, antagonist, GABA, a1, a2, α2, α1, GABAA, benzodiazepine, receptor, BZR, Tocris Bioscience, GABAA Receptor Benzodiazepine products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.