GSK 789472 hydrochloride

Cat. No. 3940

GSK 789472 hydrochloride C15H21N3O.HCl [1257326-24-1]

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Chemical Name: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one

Biological Activity

Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Holmes et al (2010) The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013. PMID: 20153647.

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Keywords: GSK 789472 hydrochloride, supplier, GSK789472, hydrochloride, dopamine, receptors, dopaminergic, D2, partial, agonists, D3, antagonists, Tocris Bioscience, D3 Receptor Antagonist products

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