TCS 5861528

Cat. No. 3938

TCS 5861528 C19H23N5O3 [332117-28-9]

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Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Biological Activity

TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in an in vivo rat model.

Technical Data

M.Wt:
369.42
Formula:
C19H23N5O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
332117-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wei et al (2010) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58 578. PMID: 20004676.

Wei et al (2010) Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. 479 253.

Wei et al (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111 147. PMID: 19512877.

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Keywords: TCS 5861528, supplier, Selective, TRPA1, blockers, antagonists, Channels, Transient, Receptor, Potential, HC030031, TCS5861528, Tocris Bioscience, TRPA1 Blocker products

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