CDP 840 hydrochloride
Cat. No. 3936
Chemical Name: 4-[(2R)-2-[3-(Cyclopentyloxy)-4-met
Biological ActivityPotent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cooper et al (1999) A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 126 1863. PMID: 10372831.
Perry et al (1998) CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 29 113. PMID: 9631241.
Hughes et al (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 118 1183. PMID: 8818342.
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Keywords: CDP 840 hydrochloride, supplier, CDP840, hydrochloride, phosphodiesterases, pde4, isoenzymes, inhibitors, inhibits, potent, selective, Tocris Bioscience, Phosphodiesterase Inhibitor products
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