CDP 840 hydrochloride

Cat. No. 3936

CDP 840 hydrochloride C25H27NO2.HCl [162542-90-7]

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Chemical Name: 4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride

Biological Activity

Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).

Technical Data

Soluble to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Cooper et al (1999) A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 126 1863. PMID: 10372831.

Perry et al (1998) CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 29 113. PMID: 9631241.

Hughes et al (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 118 1183. PMID: 8818342.

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Keywords: CDP 840 hydrochloride, supplier, CDP840, hydrochloride, phosphodiesterases, pde4, isoenzymes, inhibitors, inhibits, potent, selective, Tocris Bioscience, Phosphodiesterase Inhibitor products

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