Orphanin FQ (1-11)

Cat. No. 3932

Orphanin FQ (1-11) Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala

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Alternative Name: Nociceptin (1-11)

Biological Activity

Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.

Technical Data

Soluble to 2 mg/ml in 20% acetonitrile / water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327. PMID: 9593974.

Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858. PMID: 9262352.

Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163. PMID: 8662940.

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Keywords: Orphanin FQ (1-11), supplier, Nociceptin, Receptors, agonists, NOP, ORL1, KOR-3, analgesic, opioid, Tocris Bioscience, NOP Receptor Agonist products

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