NFAT Inhibitor

Cat. No. 3930

NFAT Inhibitor Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

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Alternative Name: VIVIT peptide

Biological Activity

Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Technical Data

M.Wt:
1683.94
Formula:
C75H118N20O22S
Sequence:
MAGPHPVIVITGPHEE
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
249537-73-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Nagamoto-Combs and Combs (2010) Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci. 30 9641. PMID: 20631193.

Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci. 101 7554.

Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 2129. PMID: 10497131.

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Keywords: NFAT Inhibitor, supplier, NFAT, Inhibitor, VIVIT, peptide, inhibits, inhibitors, calcineurin, calcineurin-mediated, dephosphorylation, nuclear, factor, of, activated, T, cells, Protein, Ser/Thr, Phosphatases, Tocris Bioscience, NFAT Inhibitor products

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