SJ 172550

Cat. No. 3929

SJ 172550 C22H21ClN2O5 [431979-47-4]

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Chemical Name: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester

Biological Activity

MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

Technical Data

M.Wt:
428.87
Formula:
C22H21ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
431979-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786. PMID: 20080970.

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Keywords: SJ 172550, supplier, disrupts, p53, MDMX, interaction, inhibitors, inhibits, SJ172550, NHPP-spermine, Tocris Bioscience, p53 Activator products

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