Cat. No. 3920
Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]ami
Biological ActivityPotent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Dominguez et al (2005) p38 MAP kinase inhibitors: many are made, but few are chosen. Curr.Opin.Drug Discov.Devel. 8 421. PMID: 16022178.
Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979. PMID: 16378500.
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Citations are publications that use Tocris products. Selected citations for AMG 548 include:
Eckle et al (2013) HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. J Biol Chem 11 e1001665. PMID: 24086109.
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Keywords: AMG 548, supplier, AMG548, potent, selective, p38alpha, p38a, p38α, inhibitors, inhibits, Tocris Bioscience, p38 MAPK Inhibitor products
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