Cat. No. 3919
Alternative Name: SC 58236
Chemical Name: 4-[5-(4-chlorophenyl)-3-(trifluorom
Biological ActivitySelective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Roche-Nagle et al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359. PMID: 15213717.
Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347. PMID: 9135032.
Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810. PMID: 8663121.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SC 236 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SC 236, supplier, SC236, SC58236, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Pfizer, Tocris Bioscience, Cyclooxygenase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective myeloperoxidase (MPO) inhibitorINCB 024360-analog
Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AACR 2017.