Cat. No. 3918

Pyrimethamine C12H13ClN4 [58-14-0]

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Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine

Biological Activity

Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Takakura et al (2011) Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet. 20 4143. PMID: 21821671.

Ito et al (2010) Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine. J.Pharmacol.Exp.Ther. 333 341. PMID: 20065018.

Zimmerman et al (1987) Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine. Am.J.Clin.Nutr. 46 518. PMID: 3630970.

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Keywords: Pyrimethamine, supplier, inhibitors, inhibits, multidrug, and, toxin, extrusion, MATE, transporters, dihydrofolate, reductase, DHFR, STAT3, signal, transducer, and, activator, of, transcription, 3, Tocris Bioscience, Multidrug Transporter Inhibitor products

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