Cat. No. 3917

Daptomycin C72H101N17O26 [103060-53-3]

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Alternative Name: LY 146032

Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone

Biological Activity

Lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in water
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501. PMID: 20522545.

Steenbergen et al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283. PMID: 15705644.

Jung et al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem.Biol. 11 949. PMID: 15271353.

Tally and DeBruin (2000) Development of daptomycin for gram-positive infections. J.Antimicrob Chemother. 46 523. PMID: 11020247.

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