Cat. No. 3917
Alternative Name: LY 146032
Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-aspar
Biological ActivityLipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501. PMID: 20522545.
Steenbergen et al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283. PMID: 15705644.
Jung et al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem.Biol. 11 949. PMID: 15271353.
Tally and DeBruin (2000) Development of daptomycin for gram-positive infections. J.Antimicrob Chemother. 46 523. PMID: 11020247.
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Keywords: Daptomycin, supplier, antibiotics, lipopeptide, Gram-positive, bacteria, infection, bacteriocidal, inhibitors, inhibits, protein, DNA, synthesis, LY146032, LY, 146032, antibacterial, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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