A 419259 trihydrochloride

Cat. No. 3914

A 419259 trihydrochloride C29H34N6O.3HCl [1435934-25-0]

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Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride

Biological Activity

Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Saito et al (2013) A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci.Transl.Med. 5. PMID: 23596204.

Pene-Dumitrescu et al (2008) An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259. Oncogene 27 7055. PMID: 18794796.

Wilson et al (2002) Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 21 8075. PMID: 12444544.

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Keywords: A 419259 trihydrochloride, supplier, A419259, Src, family, kinase, SFK, inhibitors, inhibits, apoptosis, inducers, Tocris Bioscience, Src Kinase Inhibitor products

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