HX 630

Cat. No. 3913

HX 630 C28H27NO2S [188844-52-2]

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Chemical Name: 4-(7,8,9,10-Tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl-benzoic acid

Biological Activity

RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 (Cat. No. 3507) in a HL-60 cell differentiation assay.

Licensing Information

Sold under licence.

Technical Data

Soluble to 50 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ishida et al (2003) Clinically potential subclasses of retinoid synergists revealed by gene expression profiling. Mol.Cancer Ther. 2 49. PMID: 12533672.

Ohashi et al (2002) Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines. J.Vet.Med.Sci. 64 169. PMID: 11913557.

Umemiya et al (1997) Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 40 4222. PMID: 9435893.

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Keywords: HX 630, supplier, HX630, synergists, retinoids, retinoic, pan-RXR, agonists, retinoid, synergist, Tocris Bioscience, Retinoid X Receptor products

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