HX 531

Cat. No. 3912

HX 531 C29H29N3O4 [188844-34-0]

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Chemical Name: 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid

Biological Activity

Potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.

Technical Data

M.Wt:
483.56
Formula:
C29H29N3O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
188844-34-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nie et al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624. PMID: 28099842.

Suzuki et al (2009) Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells. Biol.Pharm.Bull. 32 1177. PMID: 19571381.

Alique et al (2006) Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration. Br.J.Pharmacol. 149 65. PMID: 16847438.

Ebisawa et al (1999) Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem.Pharm.Bull. 47 1778. PMID: 10748721.

If you know of a relevant reference for HX 531 please let us know.

Citations are publications that use Tocris products. Selected citations for HX 531 include:

Nie et al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell.Rep. 18 624. PMID: 28099842.

Wnuk et al (2016) The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity. PLoS Biol 29 155. PMID: 26563996.

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Keywords: HX 531, supplier, HX531, rxrs, retinoids, x, receptors, antagonists, potent, stem, cell, differentiation, adipocytes, Tocris Bioscience, Retinoid X Receptor Antagonist products

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