Cat. No. 3910
Biological ActivitySelective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974. PMID: 19891440.
Chen et al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167. PMID: 10224072.
Lin et al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920. PMID: 10072689.
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Citations are publications that use Tocris products. Selected citations for BIO 1211 include:
Lujan et al (2015) Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 521 352. PMID: 25830878.
Fujita et al (2014) The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. PLoS One 9 e93738. PMID: 24695572.
Do you know of a great paper that uses BIO 1211 from Tocris? If so please let us know.
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Keywords: BIO 1211, supplier, Selective, high, affinity, α4β1, a4b1, alpha4beta1, very, late, antigen, VLA-4, VLA4, inhibitors, inhibits, integrins, BIO1211, Tocris Bioscience, Integrin Inhibitor products
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