Toceranib

Cat. No. 3909

Toceranib C22H25FN4O2 [356068-94-5]

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Alternative Name: Palladia

Chemical Name: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide

Biological Activity

Potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer.

Technical Data

M.Wt:
396.46
Formula:
C22H25FN4O2
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
356068-94-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Liao et al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585. PMID: 12091352.

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Keywords: Toceranib, supplier, Potent, PDGFR, VEGFR, inhibitors, inhibits, c-kit, FGFR1, mast, cell, cycle, arrest, apoptosis, tumors, tumours, Tocris Bioscience, PDGFR Inhibitor products

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