Ibutilide hemifumarate

Cat. No. 3908

Ibutilide hemifumarate C20H36N2O3S.0.5C4H4O4 [122647-32-9]

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Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate

Biological Activity

Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

Technical Data

M.Wt:
442.61
Formula:
C20H36N2O3S.½C4H4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
122647-32-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Perry et al (2004) Structural determinants of HERG channel block by clofilium and ibutilide. Mol.Pharmacol. 66 240. PMID: 15266014.

Lee and Lee (1998) Ionic mechanism of ibutilide in human atrium: evidence for a drug-induced Na+ current through nifedipine inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9. PMID: 9655836.

Murray (1998) Ibutilide. Circulation 97 493. PMID: 9490245.

Merck Index 12 4927.

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Keywords: Ibutilide hemifumarate, supplier, antiarrhythmics, ion, channel, blockers, IKr, HERG, L-type, Ca2+, channels, atrial, fibrillation, flutter, Tocris Bioscience, Other Channel Modulator products

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