Cat. No. 3906
Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-o
Biological ActivityNatural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178. PMID: 19911773.
Fulda (2008) Betulinic acid for cancer treatment and prevention. Int.J.Mol.Sci. 9 1096. PMID: 19325847.
Kashiwada et al (1996) Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. J.Med.Chem. 39 1016. PMID: 8676334.
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Citations are publications that use Tocris products. Selected citations for Betulinic acid include:
Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Neurotox Res 303 G810. PMID: 22821947.
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Keywords: Betulinic acid, supplier, antitumor, anti-HIV, NFkappaB, NF-kB, NFκB, TGR5, receptors, activators, activates, apoptosis, inducers, partial, agonists, agonism, Tocris Bioscience, Apoptosis Inducing products