Betulinic acid

Cat. No. 3906

Betulinic acid C30H48O3 [472-15-1]

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Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid

Biological Activity

Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%).

Technical Data

Soluble to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178. PMID: 19911773.

Fulda (2008) Betulinic acid for cancer treatment and prevention. Int.J.Mol.Sci. 9 1096. PMID: 19325847.

Kashiwada et al (1996) Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. J.Med.Chem. 39 1016. PMID: 8676334.

If you know of a relevant reference for Betulinic acid please let us know.

Citations are publications that use Tocris products. Selected citations for Betulinic acid include:

Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Neurotox Res 303 G810. PMID: 22821947.

Do you know of a great paper that uses Betulinic acid from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Betulinic acid, supplier, antitumor, anti-HIV, NFkappaB, NF-kB, NFκB, TGR5, receptors, activators, activates, apoptosis, inducers, partial, agonists, agonism, Tocris Bioscience, Apoptosis Inducing products

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