NAADP tetrasodium salt

Cat. No. 3905

NAADP tetrasodium salt C21H23N6Na4O18P3 [5502-96-5]

Price and Availability

For NAADP tetrasodium salt pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: NAADP

Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt

Biological Activity

Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.

Technical Data

Soluble to 50 mM in water
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Calcraft et al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596. PMID: 19387438.

Dammerman et al (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 106 10678.

Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions 34 922.

If you know of a relevant reference for NAADP tetrasodium salt please let us know.

Citations are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:

Ruas et al (2015) Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. Am J Physiol Gastrointest Liver Physiol NULL. PMID: 25872774.

Wang et al (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell 151 372. PMID: 23063126.

Do you know of a great paper that uses NAADP tetrasodium salt from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: NAADP tetrasodium salt, supplier, general, Calcium, Signaling, Signalling, Agents, Ca2+, mobilization, beta-NAADP, β-NAADP, ryanodine, receptors, Tocris Bioscience, Ryanodine Receptor Modulator products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11