NAADP tetrasodium salt
Cat. No. 3905
Alternative Name: NAADP
Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Biological ActivityCa2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Calcraft et al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596. PMID: 19387438.
Dammerman et al (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 106 10678.
Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions 34 922.
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Citations are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:
Ruas et al (2015) Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. Am J Physiol Gastrointest Liver Physiol NULL. PMID: 25872774.
Wang et al (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell 151 372. PMID: 23063126.
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Keywords: NAADP tetrasodium salt, supplier, general, Calcium, Signaling, Signalling, Agents, Ca2+, mobilization, beta-NAADP, β-NAADP, ryanodine, receptors, Tocris Bioscience, Ryanodine Receptor Modulator products
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