WAY 208466 dihydrochloride

Cat. No. 3904

WAY 208466 dihydrochloride C17H18FN3O2S.2HCl [1207064-61-6]

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Chemical Name: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride

Biological Activity

High affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
420.33
Formula:
C17H18FN3O2S.2HCl
Solubility:
Soluble to 80 mM in water and to 80 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1207064-61-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Carr et al (2010) Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 213 49. PMID: 20217056.

Schechter et al (2008) Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 33 1323. PMID: 17625499.

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Keywords: WAY 208466 dihydrochloride, supplier, WAY208466, 2HCl, serotonin, receptor, subtype, 5-hydroxytryptamine, 6, agonist, 5-HT6, agonists, Tocris Bioscience, 5-HT6 Receptor Agonist products

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