Cat. No. 3900
Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl
Biological ActivityIntegrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM). Blocks the activation of inflammatory cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974. PMID: 19891440.
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Keywords: TCS 2314, supplier, TCS2314, VLA-4, antagonist, very, late, antigen, 4, antagonists, integrin, α4β1, Tocris Bioscience, Integrin Inhibitor products
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