TCS 2314

Cat. No. 3900

TCS 2314 C28H34N4O6 [317353-73-4]

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Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid

Biological Activity

Integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM). Blocks the activation of inflammatory cells.

Technical Data

M.Wt:
522.59
Formula:
C28H34N4O6
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
317353-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974. PMID: 19891440.

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Keywords: TCS 2314, supplier, TCS2314, VLA-4, antagonist, very, late, antigen, 4, antagonists, integrin, α4β1, Tocris Bioscience, Integrin Inhibitor products

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