Cat. No. 3900
Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl
Biological ActivityIntegrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM). Blocks the activation of inflammatory cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974. PMID: 19891440.
If you know of a relevant reference for TCS 2314 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TCS 2314 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TCS 2314, supplier, TCS2314, VLA-4, antagonist, very, late, antigen, 4, antagonists, integrin, α4β1, Tocris Bioscience, Integrin Inhibitor products
Find multiple products by catalog number
New Products in this Area
Toll-like receptor (TLR) 5/Flagellin complex antagonistBioymifi
DR5 (TRAIL receptor) agonist; induces apoptosisBOP
Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCs
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.