Cat. No. 3899
Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[
Biological ActivityPotent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
Licensing InformationSold with the permission of Janssen Pharmaceutica NV
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Towart et al (2009) Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth 60 1.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JNJ 303 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JNJ 303, supplier, potent, Iks, blockers, JNJ303, potassium, K+, channels, selective, slow, delayed, rectifier, current, KCNQ1, Kv7.1, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products