Cat. No. 3899
Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[
Biological ActivityPotent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
Licensing InformationSold with the permission of Janssen Pharmaceutica NV
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Towart et al (2009) Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth 60 1.
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Keywords: JNJ 303, supplier, potent, Iks, blockers, JNJ303, potassium, K+, channels, selective, slow, delayed, rectifier, current, KCNQ1, Kv7.1, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products