Cat. No. 4041
Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazo
Biological ActivityPotent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Varani et al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101. PMID: 20331607.
Gessi et al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711. PMID: 14978250.
Baraldi et al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473. PMID: 10579811.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MRE 3008F20 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MRE 3008F20, supplier, adenosine, A3, receptors, potent, selective, competitive, antagonists, A3AR, MRE3008F20, hA3, Tocris Bioscience, Adenosine A3 Receptor Antagonist products