Cat. No. 3897
Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribo
Biological ActivityAkt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kim et al (2010) A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J.Biol.Chem. 285 8383. PMID: 20068047.
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Keywords: API-1, supplier, protein, kinase, b, pkb, akt, inhibitors, inhibits, antitumor, antitumour, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products
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