API-1

Cat. No. 3897

API-1 C13H15N5O6 [36707-00-3]

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Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

Biological Activity

Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.

Technical Data

M.Wt:
337.29
Formula:
C13H15N5O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>96 %
Storage:
Store at RT
CAS No:
36707-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Kim et al (2010) A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J.Biol.Chem. 285 8383. PMID: 20068047.

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Citations are publications that use Tocris products. Selected citations for API-1 include:

Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23. PMID: 27659207.

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. EMBO J 31 31. PMID: 22463935.

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Keywords: API-1, supplier, protein, kinase, b, pkb, akt, inhibitors, inhibits, antitumor, antitumour, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products

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