Cat. No. 3896
Alternative Name: N 0923
Chemical Name: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2
Biological ActivityDopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Also has significant affinity for 5-HT1A and adrenergic α2B receptors. Exhibits antiparkinsonian acitivity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73. PMID: 18704368.
Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.Disord. 9 147.
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Citations are publications that use Tocris products. Selected citations for Rotigotine hydrochloride include:
Fernández-Dueñas et al (2013) Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. J Exp Clin Cancer Res 63 42. PMID: 23619397.
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Keywords: Rotigotine hydrochloride, supplier, D2, D3, dopamine, agonists, receptor, N0923, parkinson's, parkinsons, Tocris Bioscience, D2 Receptor Agonist products
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